The latest liver cancer gene methylation detection in 2021
According to the latest statistics from WHO, liver cancer is the sixth most common cancer in the world, with deaths ranking third in the world, with approximately 750,000 newly diagnosed cases each year. About 8,000 people in Taiwan are diagnosed with liver cancer each year, and nearly 80% of the people die from liver cancer, and the death rate from liver cancer ranks the second highest cause of cancer death. In fact, liver cancer is not difficult to treat. It's just that the symptoms of liver cancer are not obvious. Patients are often diagnosed at the end of liver cancer. They have already missed the critical treatment period. What are the symptoms of liver cancer? What early screening method should be used to detect liver cancer early? Next, this article will sort out the 4 major liver cancer symptoms, high-risk groups of liver cancer, the latest liver cancer detection methods and liver cancer screening procedures to help you prevent potential risks of liver cancer.
Online appointment 2021 latest liver cancer gene methylation test
Who is susceptible to liver cancer? 6 high-risk groups for liver cancer
According to a report from the National Center for Biotechnology Information in the United States, 75% of patients with hepatocellular carcinoma have hepatitis B or C.
After people are infected with hepatitis B or C, some people will become chronic hepatitis, then cirrhosis, and finally liver cancer.
According to statistics, there are estimated to be more than 2.6 million hepatitis B/C carriers in Taiwan. Hepatitis B has liver cancer even 150 times that of normal people. Now Taiwan produces 30 new liver cancer patients every day! The following 6 types of people belong to the high-risk groups for liver cancer:
Fatty liver patients
Patients with abdominal ultrasound and liver abnormalities
Carriers of hepatitis B/C
Patients with liver cirrhosis
Family history of liver cancer
People who drink, smoke, and stay up late
Stages of liver cancer
Liver cancer stage 0～A: The average survival rate is greater than 5 years
Liver cancer stage B: The average survival rate is about 20 months
Liver cancer stage C: 6-14 months
Liver cancer stage D: less than three months
Souce:Clinical guideline SEOM: hepatocellular carcinoma. Sastre J, Díaz-Beveridge R, García-Foncillas J, Guardeño R, López C, Pazo R, Rodriguez-Salas N, Salgado M, Salud A, Feliu J. Clin Transl Oncol. 2015 Dec;17（12）:988-95.
Why is early screening for liver cancer important? Stage 0 detection of liver cancer can prolong survival for more than 5 years
The survival rate of liver cancer is closely related to the time of diagnosis. If liver cancer is detected early, the average survival rate is more than 5 years; when it is discovered late, the survival rate is less than 6 months; and when it is discovered at the end, the survival rate is less than 3 months! So early detection and early treatment! Therefore, the doctor recommends that the high-risk groups of liver cancer should go to the hospital for a detailed examination every six months in order to detect liver cancer as soon as possible.
What are the traditional detection methods for liver cancer? Limitations and blind spots of current early screening for liver cancer
Liver cancer is one of the most common cancers among Asians. Early liver cancer usually has no obvious symptoms and usually has advanced to an advanced stage when it is discovered, which greatly reduces the five-year survival rate of patients. Traditional liver cancer screening tools used for AFP tumor markers and abdominal ultrasound (US) cannot meet the needs of accurate early screening!
Limitations of alpha fetal protein (AFP)
Currently alpha fetal protein (AFP) and abdominal ultrasound are the first-line tools for liver cancer screening, but both have their limitations.
Statistically, in terms of AFP, only 55%～60% of liver cancer patients will have a higher AFP index.
In 30% of patients, the fetal protein index A will not increase even at the end of liver cancer.
And there are some other factors that can increase the level of fetal alpha protein and affect the correctness of liver cancer diagnosis, such as: hepatitis, liver cirrhosis, pregnancy, germ cell tumors, etc. Therefore, the normal type of fetal protein does not necessarily mean that there is no liver cancer!
A fetal white AFP is used as a test item in the annual health examination. However, in the research of Hualian Biotechnology, it is found that in the experimental liver cancer patients (confirmed patients), about 50% of the cancer patients are type A fetuses. Protein (AFP) cannot be detected! Clinical data shows that the sensitivity of AFP diagnosis is only about 50-60%, and the missed diagnosis rate is 40-50%.
Blind Spot of Abdominal Ultrasound (US)
In addition to AFP, the current liver cancer screening must also be combined with abdominal ultrasound. Ultrasound examination is painless and has no side effects, so it has become the first-line imaging tool for doctors to diagnose liver disease. However, ultrasound examination requires well-trained doctors to operate. Therefore, the detection rate is related to the doctor’s training and experience. Ultrasound itself also has its limitations. For example, some tumors grow in blind spots in ultrasonic monitoring, cannot distinguish the nature of the tumor, may miss infiltrating tumors, or the tumors are too small to be detected. In addition, fatty liver affects the transmission of sound waves. In severe fatty liver, ultrasound can assess less than half of the liver area. About 2-3 people in Taiwan have fatty liver. Therefore, ultrasound cannot completely rule out whether it is There is a tumor. According to investigations, more than 20% of liver cancers are difficult to detect with ultrasound.
The above-mentioned two traditional liver cancer detection methods have blind spots in detection. The traditional early screening tools for liver cancer, AFP tumor markers and abdominal ultrasound (US), are due to their lack of accuracy and the removal of tumors. Is the blind spot of 2-3 period! It has been unable to meet the needs of early screening of high-risk groups of liver cancer. And Hualian Biotechnology's liver cancer methylation gene detection technology (LiverEDx) can achieve a breakthrough in the early screening of "liver cancer stage 0"! Make the detection rate of early diagnosis of liver cancer higher! The sensitivity is as high as 84.2%. If you want to accurately detect early liver cancer, the best method currently is liver cancer methylation gene detection.
More accurate early detection method for liver cancer! Liver cancer methylation gene detection (LiverEDx)
Tumor DNA (ctDNA) in the blood is equivalent to the identity fingerprint of the tumor, and there will be a specific mark (methylation) on the DNA. Through genetic testing, this mark can be used to track the location of the tumor. Tumor DNA markers (methylation) usually appear in the early stages of cancer, so it is very suitable for performing early liver cancer screening. Liver cancer methylation gene detection (LiverEDx) is used for early liver cancer screening, and its detection rate is as high as 83%. It is a truly accurate early screening tool for stage 0 liver cancer. Its advantages are as follows
Breakthrough exclusive patented liver cancer methylation prediction model
Only 5cc of blood required
Early stage liver cancer (tumor <2cm) can be detected
Early screening can be advanced to liver cancer stage 0
The detection rate of early diagnosis is as high as 83%
Comparison table of 4 kinds of liver cancer detection and diagnosis tools
(#): Gastroenterology 2018; 154: 1706-1718
(*): Clinica Chimica Acta 2008; 395: 19-26
(&): Am. J. Roentgenol. 1995; 164: 885-89
Such as liver cancer methylation gene test is positive! You need to arrange to go to the hospital for computer tomography to confirm the diagnosis
Computerized Tomography (CT)
Computed tomography uses the principle of X-ray fluoroscopy to examine the characteristics of blood flow to determine whether there is liver cancer. It can also know the location and size of the tumor and whether the cancer has metastasized. It is necessary to inject a contrast agent during the examination. If the subject has renal insufficiency or is allergic to the contrast agent, it is not suitable for use.
Based on the above introduction and comparison, it can be found that methylation gene detection is currently the most accurate detection method for liver cancer. Only a small amount of blood samples are needed to accurately track tumors, screen for liver cancer as soon as possible, and grasp the golden treatment period!
Four major signs of liver cancer, the following symptoms of liver cancer should be treated as soon as possible!
The liver itself lacks pain nerves, and the body usually cannot feel it when the disease occurs. Therefore, the early symptoms of liver cancer are difficult to detect. However, if the following symptoms occur, it is likely that the liver is warning the body. It is recommended to go to the hospital for detailed examination. So as not to worsen the condition.
1. Digestive tract discomfort, long-term unexplained diarrhea
Many liver cancer patients have symptoms of digestive discomfort such as decreased appetite, gas after meals, indigestion, and nausea in the early stages. This type of disease is often misdiagnosed as stomach disease, leading to missed opportunities for early treatment.
2. Unexplained fatigue
The fatigue caused by liver cancer is different from the general feeling of fatigue. Even if you increase the rest and sleep time, it cannot be easily eliminated, leaving people in a state of lack of energy for a long time.
3. Sudden and rapid weight loss
When all living habits are normal and there is no intention to lose weight, a sudden weight loss of more than 10 kg indicates that the body's function of absorbing and preserving nutrients is malfunctioning, and it is also likely to be a precursor to liver cancer.
4. Lumps appear under the ribs on the right side and in the upper right abdomen
The liver is located in the upper right abdomen of the body, below the diaphragm. If there is a hard lump or even pain in this part of the body, it may be that the liver cancer has entered the middle and advanced stages, and the tumor is too large to oppress the peripheral nerves.
The four major liver cancer symptoms mentioned above are actually very similar to the symptoms of abnormal digestive system. Therefore, most people don't care even if they have severe symptoms and often miss the golden treatment period. If you want to diagnose liver cancer, the best way is to go to the hospital for detailed examinations on a regular basis, especially in high-risk groups that are prone to liver cancer.
"Liver Cancer Methylation Gene Test" | Early screening for liver cancer protects your health
This is currently the only manufacturer of high-density genetic chips in Asia, and one of the world's four largest high-density genetic chip research and development factories. The core capabilities focus on the development of genetic testing platforms, with genetic testing and analysis technologies such as microarray, next-generation sequencing (NGS), and big data analysis.
It has the energy for self-development, design, and production, and continues to develop a variety of genetic chips and testing services for "prenatal rare disease detection", "disease risk prediction and physical testing"! Especially in the early screening market, the exclusive patented "ctDNA-based early screening for liver cancer" test service was launched in 2019. The following are 5 major advantages
Breakthrough exclusive patented liver cancer methylation prediction model
Only 5cc of blood required
Early stage liver cancer (tumor <2cm) can be detected
Early screening can be advanced to liver cancer stage 0
The detection rate of early diagnosis is as high as 83%
Four major steps in the screening process of liver cancer methylation gene detection:
Fill in the test instructions: the medical staff will explain the precautions related to the test in detail.
Blood collection: After fully understanding the relevant precautions, collect peripheral blood samples and store them at low temperature (4°C) for testing.
Detection and analysis: The methylation gene detection of liver cancer is carried out by a professional gene body laboratory.
Inspection report: The inspection report can be obtained after 10 working days.
Liver cancer methylation gene detection is a non-invasive treatment. You can get a complete liver cancer gene test report with a simple blood draw. If you are a high-risk group of liver cancer, it is recommended to screen early and go to the hospital regularly to prevent The potential risk of liver cancer.
Online appointment 2021 latest liver cancer gene methylation test
2021 Liver Cancer Methylation Test _QA
Common Q&A
Q1: Are there any clinical trials for liver cancer methylation products?
Ans:
The R&D team has cooperated with 4 teaching hospitals to verify thousands of clinical specimens before the product goes on the market, and its sensitivity and specificity are more than 80%.
Cooperative hospitals include
National Cheng Kung University Hospital, Chi Mei Hospital, Kaohsiung Medical University Affiliated Hospital and Taipei Veterans General Hospital, with a total of 1054 cases:
* The first batch of trials was conducted at Chengda Hospital, and 697 cases were accepted;
* The second batch of trials was carried out in 4 hospitals at the same time, and a total of 357 cases were accepted.
Q2: Today, the patient is a high-risk liver cancer patient. The doctor recommends that the patient undergo a methylation test. The detection is really high-risk, then what?
Ans:
CT/MRI is recommended
Q3: Have you ever encountered AFP positive and negative methylation conditions? If so, how will it be handled in the future?
Ans:
The problem with AFP is that the sensitivity is not high. If AFP is positive, according to the current clinical treatment, doctors need to monitor and deal with it. The sensitivity of methylation is higher than that of AFP, and the proportion of AFP positive but negative for methylation is very low, only about 3.5%.
Q4: If the ultrasound is abnormal, does it mean that methylation must be positive?
Ans:
The abnormal image is not necessarily cancer. Generally benign tumors can also be detected by ultrasound. Methylation detection can be used as a safe, simple and reliable diagnostic tool.
Q5: The doctor asked, if the first test is low-risk, the second test is also low-risk, but the risk value is significantly increased. How to explain the evaluation?
Ans:
Methylation screening is to detect the degree of methylation of 4 genes, supplemented by algorithmic determination. If the value is increased, there may be 2-3 genes whose degree of methylation changes, but the risk of liver cancer is still low.
Q6: Is it possible that the first test is positive and the second test is negative?
Ans:
If in the early stage of liver cancer, when there are not many cancer cells, it may happen, because NK cells will eliminate cancer cells (one of the principles of cell therapy), so there is a chance to produce negative results. There has been no case where the second sampling is negative. It takes about 117 days for the cancer cells to grow one centimeter in the early stage of liver cancer, so it is recommended that they must be reviewed every 6 months. Even if it is negative for the second time, it is recommended to follow up again after 6 months to avoid a sudden and rapid increase in cancer cells after the immune system declines.
Q7: Is methylation reversible? How is it different from genes or inheritance?
Ans:
1. DNA methylation performs many normal physiological functions. Some methylation is reversible and some is irreversible.
2. DNA methylation is a mechanism that regulates gene expression.
Q8: If patients in the high-risk group have normal ultrasound and AFP examinations every three months, where should the methylation be cut?
Ans:
Abdominal ultrasound has some blind spots in the early screening of liver cancer:
For example: operating experience, tumor size, location, fatty liver, tumor type (diffuse type/infiltrating type) will cause the abdominal ultrasonography to be undetectable
According to the 2018 review paper (Gastroenterology 2018;154:1706), the sensitivity of abdominal ultrasonography in the early screening of liver cancer is only about 25.6%-65%. The performance of AFP in the early screening of liver cancer is weaker: the sensitivity is only about 20%. This is why the liver cancer screening test AFP+Abdominal Ultrasound has been implemented for many years (sensitivity is about 32.6%-74.8%), but most liver cancers are found in the middle and late stages. Liver cancer is still the second leading cause of death among the top ten cancers in China. It is obvious that the existing liver cancer screening methods There is a lot of room for improvement.
Q9: Is it necessary for patients with high-risk patients to undergo our tests before CT or MRI? The change in our role is just to reconfirm the patient as a high-risk patient?
Ans:
People at high risk cannot go to CT or MRI often. 2% of people are allergic to imaging agents and more than 20% of liver cancers (diffuse/infiltrating) are ultrasound, and even CT is difficult to distinguish.
Q10: The doctor asked whether the methylation test would be interfered by acute hepatitis or other diseases?
Ans:
Acute hepatitis will not interfere.
Q11: Can hepatitis E virus be tested for methylation (hepatitis A, B, and C are all tested, but the liver index is abnormally high)?
Ans:
No, because the methylation of liver cancer is to detect liver cancer, not to detect the hepatitis E virus HEV. .
Q12: Does the company's methylation detection products have comparative data on the external factors of "daily life patterns, drugs, and alcoholism"?
Ans:
There are few studies on the effects of lifestyle, drugs, alcoholism, etc. on gene methylation, but many research papers have confirmed that it will affect it. However, liver cancer methylation products are tested for liver cancer-specific genes. The impact of these liver cancer-specific genes on lifestyle, drugs, and alcoholism has not been reported.
Q13: Regarding the accuracy rate, will the methylation detection match the results of clinical slices?
Ans:
The liver cancer methylation test measures plasma free DNA, which is released from liver cancer cells. When we develop it, we first verify from tissue samples and then proceed to plasma free DNA verification. Therefore, the detected gene methylation will be related to tumors. Consistent organization.
Q14: Is there a positive correlation between viral load and methylation?
Ans:
There is no correlation between liver cancer and the amount of virus. Our methylation is to detect liver cancer, so it will not be correlated with the amount of virus.
Medical examiner's side
Q1: The health examiner asks: Just a scan of the abdomen and super ABD ~ Why do this genetic test?
Ans:
1. Abdominal ultrasonography has some blind spots in the early screening of liver cancer, such as: operating experience, tumor size, location, fatty liver, tumor type
State (diffuse type/infiltrating type) will cause the abdominal ultrasonography to be undetectable
According to the 2018 review paper (Gastroenterology 2018;154:1706)
The sensitivity of abdominal ultrasonography in the early screening of liver cancer is only about 25.6%-65%. This is why liver cancer screening AFP+abdomen
Ultra (sensitivity is about 32.6%-74.8%) has been implemented for many years, but most liver cancers are already in the middle and late stages when they are discovered.
Liver cancer is still the second leading cause of death from the top ten cancers in China. It is obvious that there is much room for improvement in the existing screening methods for liver cancer.
2. Methylation screening in the early detection rate of liver cancer can reach 83%
For patients whose abdominal ultrasonography is difficult to judge, such as invasive liver cancer, patients with high AFP values but no abnormalities found on abdominal ultrasonography
Etc., methylation screening can provide another set of indicators for judgment.
Q2: The health manager asks: The person who came for the health check in the clinic is not sick! Why do you need a genetic test?
Ans:
1. Groups at high risk of liver cancer include hepatitis virus infection, chronic hepatitis patients, liver cirrhosis, obesity, alcoholism, and type 2 diabetes
Disease, genetic metabolic syndrome, yellow koji toxin, arsenic pollution, smoking, etc. Although these people have not yet developed symptoms, but
Belonging to sub-healthy people, the incidence of liver cancer is higher than that of normal healthy people, and they need to be tracked regularly. If the results of the health check are as described above
If the condition is abnormal, it is recommended to do liver cancer methylation test.
2. Hepatitis virus infection is the most important factor in the occurrence of liver cancer. It is estimated that there are about 2.5 to 3 million people living with liver B in Taiwan.
However, according to WHO statistics, about 65-75% of the global population infected with hepatitis virus are infected without knowing it.
Q3: After the test: What is the description of the clinical diagnosis result (negative/positive) of the docking? solution?
Ans:
Screening and diagnosis have different positioning in cancer detection
"Screening" is the detection of possible disease factors. The main detection targets are asymptomatic but may be high-risk groups.
Because the operation is simple and fast, the price is usually low and the accuracy is not high.
"Confirmed" is to confirm whether there is a disease, and the target is a symptomatic individual or an asymptomatic individual with abnormal screening.
It is usually expensive, or invasive, and requires high accuracy.
No test is currently 100% correct: * Am J Gastroenterol 2006;101:513–523
Even for CT or MRI for diagnosis, the sensitivity is only 68% and 81%*, respectively.
No single test can detect 100% of all liver cancers, so multiple tests must be diagnosed together.
Methylation testing is positioned as a "screening". The purpose of screening is to identify possible high-risk groups, and then confirm with diagnostic tools. At present, the sensitivity of methylation screening has reached 84.2%, which is far better than the current screening tools AFP and abdominal ultrasound. However, about 20% of people may not be able to detect it. For the screening tool, the sensitivity of AFP in the early detection is about 55-60%, The sensitivity of ultra-early abdominal screening is about 25.6%-65%, and currently methylation detection is the best choice.
Q3-1: Is it possible that the first test is positive and the second test is negative?
1. If in the early stage of liver cancer, when there are not many cancer cells, it may happen, because NK cells will eliminate
One of the principles of cell therapy), so there is a chance to produce negative results. There has been no case where the second sampling is negative.
It takes about 117 days for the cancer cells of the initial liver cancer to grow to one centimeter, so it is recommended that the examination should be performed every 3-6 months. Even if it is negative for the second time, it is recommended to follow up again after 6 months to avoid a sudden and rapid increase in cancer cells after the immune system declines.
Cancer cells are caused by abnormal division of normal cells. The cells themselves have many mechanisms to prevent abnormal cell division. For example,
Such as: DNA repair genes, tumor suppressor genes, autophagy
Use (apoptosis) and so on, even if the cells
Failure of these mechanisms results in the production of cancer cells, but there is also an immune system in the body that can eliminate cancer cells, such as killer T cells.
Cells (cytotoxic T cells), natural killer cells (nature killer cells), etc.
2. Since methylation detection can detect cancer cells at a very early stage, and is a dynamic screening test, the external environment, drinking water
Eating, etc. will affect the formation of cancer cells, as well as the cell and immune system's cancer cell elimination mechanism. The formation and elimination of cancer cells in the body is in a dynamic balance. If the mechanism in the body successfully eliminates cancer cells, it may be tested negative later. .
Q4: I would like to ask the senior examiner, is there a green channel to connect to the hospital window after the test? Doctors who use cognitive methylation gene testing
Ans:
1. Department of Hepatobiliary and Pancreatic Surgery, National Taiwan University Hospital, Dr. Huang Kaiwen/Attending Professor
* High-risk groups who receive methylation tests referred to by the health check center and have a red letter
* If the doctor from Taiwan University Huang Kaiwen is full, he can tell the counter that hepatocarcinoma methylation test is positive, and he can add another sign.
2. Department of Gastrointestinal Hepatobiliary, Taipei Veterans General Hospital Zhu Qiren Attending physician/associate professor.
3. Department of Gastroenterology, Taipei Tzu Chi Hospital Xu Jingsheng Attending physician/associate professor.
4. Department of Hematology and Oncology, Affiliated Hospital of Cheng Kung University Yan Jiarui Attending physician/professor.
5. Tainan Municipal Hospital/E-Da Hospital, Gastrointestinal Hepatobiliary Department Mou Lianrui Dean/Vice President.
Q5: Dynamic testing: not cheap, it needs to be tested many times: how to persuade to do it every six months?
Ans:
1. According to the research on the growth rate of liver cancer by Professor Xu Jinchuan from National Taiwan University Hospital, the median time for the volume of liver cancer to double is 112
Days, the fastest is 29 days. Calculated in 29 days, it takes four to six months for liver cancer to grow from 1 cm to 3 cm. Therefore, it is recommended to do an inspection six months.
2. Health checkups are done every year, but when liver cancer is found, it is in the terminal stage, and cases where surgery cannot be performed are heard from time to time. The current tools for liver cancer screening
Insufficient sensitivity, high-risk groups of liver cancer, such as: hepatitis virus infection, chronic hepatitis patients, liver cirrhosis, obesity, alcoholism, type 2 diabetes, genetic metabolic syndrome, yellow yeast toxin or arsenic pollution, smokers, etc., are at risk of cancer It is a hundred times higher than normal people. It is recommended that people who pay attention to their own health take regular liver cancer screenings every year, including: AFP, abdominal ultrasonography and methylation tests.
3. There is no good chemotherapy or targeted drug treatment for liver cancer. Early detection can be surgically removed. The average survival rate can reach five years, but if it is discovered at the end, the average survival rate is only about 3 months. Early detection and early treatment are especially important for liver cancer. important.
4. If liver cancer is detected early, the average length of hospital stay is about 15 days, and the operating expenses are paid by Taiwan's health insurance, and only part of the self-funded items need to be paid, about 30,000 to 50,000. However, if it is found in the middle and late stages, the average length of hospital stay is 114 days, and surgical treatment is not possible. If the targeted drug treatment fails to apply for health insurance, it will cost more than 1 million. This will not only reduce the quality of life of individuals and their families, but also cause a heavy burden on the family.
Q1: Dynamic testing: Not cheap, it needs to be tested many times: Is it done every six months?
Ans:
ctDNA is the free tumor-derived DNA in the blood of patients, which is a highly sensitive and highly specific tumor marker. It is equivalent to the "identity fingerprint" released by tumor cells into the blood. Because it carries methylation changes that are quite consistent with the primary tumor tissue, ctDNA can be used for early screening of liver cancer! By extracting free tumor DNA and performing methylation sequencing, analyzing the methylation pattern to determine the location of the tumor, thereby determining the tissue source of the tumor.
Q2: Why does ctDNA methylation screening help early detection of cancer?
Ans:
When normal cells become cancerous, the CpG region of a specific gene will be highly methylated! It can cause changes in chromatin structure, DNA conformation, DNA stability, and the way of interaction between DNA and protein, which in turn affects gene transcription and expression and induces cancer development. Abnormal DNA methylation occurs in the early stage of tumor formation, so it is an ideal marker for early tumor diagnosis!
Q3: What is the methylation gene test for early screening of liver cancer?
Ans:
By detecting the degree of gene methylation at specific sites of circulating tumor DNA (ctDNA) in a small amount of blood, and with a unique liver cancer methylation prediction model patent technology, it can greatly improve the performance of liver cancer screening, allowing the silent killer "liver cancer" to be detected early, Early treatment greatly improves patient treatment and survival rates.
Q4: Why do we need to be screened for liver cancer?
Ans:
Liver cancer is one of the most common cancers among Asians. It is the fifth most common cancer in the world and the second most fatal cancer. It has no obvious symptoms in the early stage, and it has mostly advanced to the advanced stage when it is discovered. Early detection and early treatment can greatly increase the survival rate of liver cancer.
Q5: Why use ctDNA methylation gene detection for liver cancer?
Ans:
Traditional liver cancer screening tools, α-fetal protein (AFP) tumor markers and abdominal ultrasound (US), cannot meet the needs of accurate early screening! Hepatocarcinoma methylation gene detection, through the detection of the degree of methylation of genes at specific sites in circulating tumor DNA (ctDNA) in the blood, and with the unique patented technology of liver cancer methylation prediction model, it can greatly improve the performance of liver cancer screening and reduce the early stage of liver cancer. The sensitivity of diagnosis increased from 50% to 84.1%.
Q6: What are the advantages of ctDNA methylation detection for liver cancer?
Ans:
Non-invasive detection, high sensitivity, high specificity, it can be detected in the very early stage of liver cancer. Experiments have confirmed that among a group of confirmed cancers, nearly 50% of the current traditional tests for α-fetal protein (AFP) cannot detect cancers, but liver cancer methylation gene testing (MPM) can detect cancers from these cancers. Among those detected, 75% more cancer patients are detected! It can complement the limitations of existing detection tools and meet the needs of accurate early screening!
Q7: Five characteristics of ctDNA methylation detection for liver cancer
Ans:
#Dynamic, accurate and dynamic repetitive gene detection
#Non-invasive, non-invasive testing
#Early, abnormal methylation marker changes can be detected in the early stage of cancer (tumor <1cm)
#Accurate, clinical trials have confirmed that the sensitivity of liver cancer screening is 84.2% and the specificity is 83.0%
#Patent, Taiwan, United States, China
Q8: What is the principle of ctDNA methylation detection for liver cancer?
Ans:
This test system separates the plasma from the peripheral blood of the subject, extracts cell-free DNA (cfDNA), and treats it with bisulfate to convert the cytosine on the CpG island of the DNA into uracil (U), 5-methylcytosine cannot be converted to uracil. After sulfite-treated cfDNA, quantitative methylation-specific PCR (qMSP) was used to analyze the degree of methylation of specific genes. The quantitative results use the liver cancer methylation prediction model to predict the potential risk of the subject of liver cancer.
Q9: Who is the target of the methylation gene test for early screening of liver cancer?
Ans:
High-risk groups of liver cancer: hepatitis B virus carriers, hepatitis C virus carriers.
Q10: What is the service process of early screening methylation detection for liver cancer?
Ans:
1. The medical personnel explain and explain, understand the precautions related to this test, and fill in the test manual
2. Peripheral blood/plasma sample collection, low temperature (4℃) storage and submission
3. Genome laboratory conducts liver cancer methylation gene detection
4. Get the report after 10 working days
Q11: I want to be tested. I should go there for blood collection. What do I need to explain to the service staff?
Ans:
1. Taipei City-Songshan District, No. 218, Section 5, Minsheng East Road, Minsheng Medical Technologist-kao Medical Technologist
2. Phone: 02-27698340
3. Report time: 2 weeks
Online appointment 2021 latest liver cancer gene methylation test